A daunting proposition

Biological Control of Appetite: A Daunting Complexity

OBJECTIVE This review summarizes a portion of the discussions of an NIH Workshop (Bethesda, MD, 2015) titled "Self-Regulation of Appetite-It's Complicated," which focused on the biological aspects of appetite regulation. METHODS This review summarizes the key biological inputs of appetite regulation and their implications for body weight regulation. RESULTS These discussions offer an update...

A daunting task: manipulating leukocyte function with RNAi.

RNA interference (RNAi) has advanced into clinical trials. In spite of the progress made in systemic RNAi delivery to the liver and solid tumors, delivery of RNAi to leukocytes remains challenging and less advanced. Manipulating leukocyte function with RNAi holds great promise for streamlining the drug discovery process by facilitating in vivo drug target validation and for facilitating the dev...

Robotics. Shape shifters tread a daunting path toward reality.

754 From Star Trek to Star Wars to Terminator, science-fiction movies and TV series teem with morphing robots. If that vision is indeed a sneak preview of things to come, then the future of robotics is lying face down on a table in Mark Yim’s laboratory at the Palo Alto Research Center (PARC) in California. Or rather, was lying face down, because now it’s trying to stand up. First, the 30-centi...

A national proposition?

Detection of innocuous temperatures allows an organism to select an appropriate environmental climate, while the ability to recognize noxious temperature extremes warns of impending tissue damage. For temperatures considered cold, the menthol receptor TRPM8 is activated when temperatures drop below ~26°C, thus making it an intriguing candidate as the molecular mediator of cold perception. Howev...

Fermi's Paradox Is a Daunting Problem-Under Whatever Label.